The announcement comes after the director of Antonio Yapor Heded Hospital, Dr. Emmanuel Oscar Perez, on Monday said at least seven doctors, 18 nurses and 19 administrative employees at the hospital have tested positive so far.
The minister said that a possible "biosecurity failure" could have caused the outbreak at the hospital.
He added that experts from the capital, Santo Domingo, along with members of the Emergency Operations Center and local authorities will be heading to the hospital to assist to contain the outbreak.
CNN has reached out to the hospital for comment.
The Dominican Republic has so far registered 74,295 coronavirus cases and 1,213 deaths, according to Johns Hopkins University.