The totals includes cases from all 50 states, the District of Columbia and other U.S. territories, as well as all repatriated cases.
Wyoming is the only state that is not reporting a death from coronavirus.
The projections are based on new modeling scenarios run by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington that assume social distancing policies will end from next month.
"The risk of rebound is very great," IHME Director Dr. Chris Murray told CNN late Friday.
The projections are based on new modeling scenarios run by IHME that assume social distancing policies will end from next month.
"If we were to stop at the national level May 1st, we're seeing (in models) a return to almost where we are now sometime in July, so a rebound ... Definitely there's a very substantial risk of rebound if we don't wait to the point where most transmission is near zero in each state."
The research center plans to release state-level analyses based on the new models next week, Murray said.
The warning comes after Trump said he wanted to reopen the country's economy, despite many researchers and medical staff saying it's far too early for such a move.