Manzanero was hospitalized in mid-December after testing positive for Covid-19, CNN reported at the time.
Manzanero was a prolific composer with more than 600 songs to his name, according to the Mexican Society for Authors and Composers. Some of his songs were interpreted by artists from around the world such Elvis Presley, Dionne Warwick, Perry Cuomo, Spanish singer Raphael, and fellow Mexican start Luis Miguel.
The Latin Recording Academy & Latin Grammy expressed their sympathy for Manzanero's passing: "Armando Manzanero received the Award for Musical Excellence and was the winner of the Latin Grammy, he was also a great friend that is now gone. We celebrate his live and world. An irreplaceable loss for the Latin music world. We are with the Manzanero family in their grief."
Manzanero won a Latin Grammy in 2001 for his album "Duets". He later went on to win a Lifetime Achievement award in 2014, becoming the first Mexican to receive this honor.
Mexican President Andres Manuel Lopez Obrador expressed condolences in the artist's passing.
"Armando Manzanero was a sensitive man, a man of the people. That's why I lament his death. He was also a great composer. He also represented Mexican authors and composers," he said during a press conference on Monday.
Mexico's Secretary of Culture, Alejandra Frausto, released a statement on Twitter, saying she mourns the death "of the Yucatecan musician Armando Manzanero, author of hundreds of songs performed by national and international artists, and a great connoisseur of the bolero tradition of Latin America. RIP."
Manzanero will be cremated in Mexico City and his remains will be taken to his hometown of Merida, in Mexico's Yucatan state.