On Wednesday, Aston Villa hosts Sheffield United, while Manchester City faces Arsenal. All of the league's remaining 92 fixtures will be held behind closed doors.
However, a recent YouGov survey found that 48% of adults thought the Premier League was returning too soon as the UK emerges tentatively from lockdown.
The restart comes at a point when some regions, such as the northwest of England, have been identified as potential hotspots for the virus with infection rates decreasing more slowly.
There have also been concerns whether fans might congregate outside of stadiums, notably in the city of Liverpool where Jurgen Klopp's side could clinch its first league title in 30 years with victory over local rival Everton on Sunday if Arsenal beats Manchester City.
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